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K+ voltage-gated channel subfamily A member 3; voltage-gated K+ channel subunit Kv1.3; HPCN3; HGK5; HuKIII; HLK3 (KCNA3, HGK5)
Function:
- mediates the voltage-dependent K+ permeability of excitable membranes
- assumes opened or closed conformation in response to voltage difference across membrane
- forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
- heterotetramer of K+ channel proteins
- binds PDZ domains of DLG1, DLG2 & DLG4 (putative)
Structure:
- the N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, A (Shaker) subfamily
Compartment: membrane
Note: uncertain whether Met-1 or Met-53 is the initiator
General
glycoprotein
phosphoprotein
voltage-gated K+ channel alpha subunit
Properties
SIZE: entity length = 575 aa
MW = 64 kD
COMPARTMENT: plasma membrane
MOTIF: N-glycosylation site {N109}
transmembrane domain {235-253}
N-glycosylation site {N279}
transmembrane domain {295-316}
cysteine residue {C317}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {328-348}
transmembrane domain {363-381}
transmembrane domain {398-417}
peptide motif {444-449}
transmembrane domain {459-481}
Ser phosphorylation site {S520}
peptide motif {573-575}
ION-PERMEABILITY: K+
Database Correlations
OMIM 176263
UniProt P22001
PFAM correlations
Entrez Gene 3738
Kegg hsa:3738
References
UniProt :accession P22001