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post-GPI attachment to proteins factor 3 (PER1-like domain-containing protein 1, gene coamplified with ERBB2 protein, hCOS16, PERLD1, CAB2, PGAP3, UNQ546/PRO1100)
Function:
- role in the lipid remodeling steps of GPI-anchor maturation
- role in metabolism of saturated fatty chains at the sn-2 position of glypiated proteins
- required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (probable)
Structure: belongs to the PGAP3 family
Compartment:
- Golgi membrane, endoplasmic reticulum membrane
- mainly localizes to Golgi
Alternative splicing: named isoforms=2
Expression:
- ubiquitously expressed
- highest levels in thyroid & placenta
Comparative biology:
- when transfected in S.cerevisiae, it can complement the absence of yeast of PER1 protein, suggesting a conserved role in lipid remodeling steps of GPI-anchor maturation
General
glycoprotein
transmembrane 7 protein
Properties
SIZE: entity length = 320 aa
MW = 36 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: exoplasmic domain {1-98}
MOTIF: signal sequence {1-20}
N-glycosylation site {N40}
transmembrane domain {99-119}
cytoplasmic loop {120-135}
transmembrane domain {136-156}
exoplasmic loop {157-169}
transmembrane domain {170-190}
cytoplasmic loop {191-193}
transmembrane domain {194-214}
exoplasmic loop {215-224}
transmembrane domain {225-245}
cytoplasmic loop {246-257}
transmembrane domain {258-278}
exoplasmic loop {279-279}
transmembrane domain {280-299}
cytoplasmic domain {300-320}
Database Correlations
UniProt Q96FM1
Pfam PF04080
Kegg hsa:9321
References
UniProt :accession Q96FM1