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E3 ubiquitin-protein ligase RAD18; postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73 (RAD18, RNF73)
Function:
- E3 ubiquitin-protein ligase
- involved in postreplication repair of UV-damaged DNA
- postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA
- associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on Lys-164
- has ssDNA binding activity
- protein modification; protein ubiquitination
- interacts with UBE2A & UBE2B
- interacts with HLTF & SHPRH
Structure:
- belongs to the RAD18 family
- contains 1 RING-type Zn+2 finger
- contains 1 SAP domain
- contains 1 UBZ-type Zn+2 finger
Compartment: nucleus (putative)
Related
DNA repair
General
nuclear protein
phosphoprotein
ring finger protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 495 aa
MW = 56 kD
COMPARTMENT: cell nucleus
MOTIF: RING-finger {25-64}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S99}
Ser phosphorylation site {S103}
Ser phosphorylation site {S107}
Thr phosphorylation site {T118}
Ser phosphorylation site {S158}
Ser phosphorylation site {S164}
Zinc finger
NAME: Zinc finger
SITE: 201-224
EFFECTOR-BOUND: Zn+2
SAP {248-282}
Ser phosphorylation site {S322}
Ser phosphorylation site {S403}
Ser phosphorylation site {S409}
Ser phosphorylation site {S471}
Database Correlations
OMIM 605256
UniProt Q9NS91
Pfam PF02037
Entrez Gene 56852
Kegg hsa:56852
References
- UniProt :accession Q9NS91
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad18/