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poly(A) polymerase gamma; PAP-gamma; neo-poly(A) polymerase; neo-PAP; polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme (PAPOLG, PAP2, PAPG)
Function:
- post-transcriptional adenylation of 3'-terminal small RNAs including:
- signal recognition particle (SRP) RNA
- nuclear 7SK RNA
- U2 small nuclear RNA
- ribosomal 5S RNA
Cofactor:
- binds 2 Mg+2
- also active with Mn+2
Structure: belongs to the poly(A) polymerase family
Compartment: nucleus
Expression:
- expressed predominantly in testis
- weakly in other tissues
- overexpressed in several tumors
General
nuclear protein
phosphoprotein
poly[A]polymerase
Properties
SIZE: entity length = 736 aa
MW = 83 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S23}
Ser phosphorylation site {S29}
ATP-binding site
NAME: ATP-binding site
SITE: 99-101
ATP-binding site
NAME: ATP-binding site
SITE: 108-108
ATP-binding site
NAME: ATP-binding site
SITE: 112-114
MOTIF: Mg+2-binding site
SITE: 112-112
Mg+2-binding site
SITE: 114-114
phenylalanine residue {152}
lysine residue {157}
Mg+2-binding site
SITE: 166-166
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 166-166
ATP-binding site
NAME: ATP-binding site
SITE: 227-227
ATP-binding site
NAME: ATP-binding site
SITE: 236-236
ATP-binding site
NAME: ATP-binding site
SITE: 245-246
asparagine residue {327}
arginine residue {398}
aspartate residue {532}
Ser phosphorylation site {S552}
Thr phosphorylation site {T597}
Ser phosphorylation site {S599}
Ser phosphorylation site {S648}
Thr phosphorylation site {T654}
Ser phosphorylation site {S684}
Database Correlations
UniProt Q9BWT3
PFAM correlations
Entrez Gene 64895
Kegg hsa:64895
ENZYME 2.7.7.19
References
UniProt :accession Q9BWT3