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polyserase-3; polyserine protease 3; protease serine S1 family member 53 (PRSS53)
Function:
- in vitro can degrade the fibrinogen alpha chain & pro-urokinase-type plasminogen activator
- influences hair shape (hair curliness)
Structure:
- belongs to the peptidase S1 family
- contains 2 peptidase S1 domains
Compartment: secreted
Expression:
- predominantly detected in testis, liver, heart & ovary, as well as in several tumor cell lines
- highly expressed in the hair follicle, especially the inner root sheath [2]
General
hydrolase
secreted protein
Properties
SIZE: entity length = 553 aa
MW = 58 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
S1 domain {24-273}
MOTIF: cysteine residue {C62}
MODIFICATION: cysteine residue {C78}
histidine residue {H77}
cysteine residue {C78}
MODIFICATION: cysteine residue {C62}
aspartate residue {D128}
cysteine residue {C158}
MODIFICATION: cysteine residue {C230}
cysteine residue {C187}
MODIFICATION: cysteine residue {C209}
cysteine residue {C209}
MODIFICATION: cysteine residue {C187}
cysteine residue {C220}
MODIFICATION: cysteine residue {C249}
serine residue {S224}
cysteine residue {C230}
MODIFICATION: cysteine residue {C158}
cysteine residue {C249}
MODIFICATION: cysteine residue {C220}
S1 domain {294-526}
MOTIF: cysteine residue {C326}
MODIFICATION: cysteine residue {C342}
histidine residue {H341}
cysteine residue {C342}
MODIFICATION: cysteine residue {C326}
aspartate residue {D382}
cysteine residue {C444}
MODIFICATION: cysteine residue {C464}
cysteine residue {C464}
MODIFICATION: cysteine residue {C444}
cysteine residue {C474}
MODIFICATION: cysteine residue {C502}
serine residue {S478}
cysteine residue {C502}
MODIFICATION: cysteine residue {C474}
Database Correlations
UniProt Q2L4Q9
Pfam PF00089
Kegg hsa:3391
References
- UniProt :accession Q2L4Q9
- Adhikari K, Fontanil T, Cal S et al
A genome-wide association scan in admixed Latin Americans
identifies loci influencing facial and scalp hair features.
Nat Commun. 2016 Mar 1;7:10815.
PMID: 26926045