polypyrimidine tract-binding protein 1; PTB; heterogeneous nuclear ribonucleoprotein I; hnRNP I; 57 kD RNA-binding protein PPTB-1 (PTBP1, PTB)

Function: - plays a role in pre-mRNA splicing - binds to the polypyrimidine tract of introns - may promote the binding of U2 snRNP to pre-mRNA - cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA - component of FUBP2/PTBP1/PTBP2/HNRPH1 complex - interacts with RAVER1 & SFPQ Structure: - monomer - contains 4 RRM domain (RNA recognition motif)s Compartment: nucleus Alternative splicing: named isoforms=2 comment=additional isoforms seem to exist

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 531 aa MW = 57 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S16} RNP motif NAME: RNP motif SITE: 59-143 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Tyr phosphorylation site {Y127} Ser phosphorylation site {S141} RNP motif NAME: RNP motif SITE: 184-260 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif alanine-rich region {316-323} MOTIF: alanine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 337-411 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S433} RNP motif NAME: RNP motif SITE: 454-529 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM 600693 UniProt P26599 Pfam PF00076 Entrez Gene 5725

References

UniProt :accession P26599