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polypeptide N-acetylgalactosaminyltransferase 18; polypeptide galNAc transferase-like protein 4; galNAc-T-like protein 4; pp-GaNTase-like protein 4; polypeptide N-acetylgalactosaminyltransferase-like protein 4; protein-UDP acetylgalactosaminyltransferase-like protein 4; UDP-galNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4 (GALNT18 GALNTL4)
Function:
- may catalyze initial reaction in O-linked oligosaccharide biosynthesis, transfer of N-acetyl-D-galactosamine residue to Ser or Thr on the nascent glycoprotein
UDP-N-acetyl-D-galactosamine + polypeptide UDP + N-acetyl-D-galactosaminyl-polypeptide
Cofactor: Mn+2, Ca+2
Structure:
- belongs to glycosyltransferase 2 family, GalNAc-T subfamily.
- two conserved domains in the glycosyltransferase region:
a) N-terminal domain (domain A, GT1 motif)
- Mn+2 coordination & substrate binding
b) C-terminal domain (domain B, Gal/GalNAc-T motif)
- catalytic reaction & UDP-Gal binding
- ricin B-type lectin domain binds to GalNAc & contributes to glycopeptide specificity
Compartment: Golgi membrane
Alternative splicing: named isoforms=2
General
galactosyltransferase
glycoprotein
Properties
SIZE: entity length = 607 aa
MW = 70 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {13-35}
N-glycosylation site {N146}
active site
SITE: 153-267
MOTIF: N-glycosylation site {N195}
N-glycosylation site {N320}
active site
SITE: 324-385
Ricin B-type lectin {469-599}
MOTIF: cysteine residue {C482}
MODIFICATION: cysteine residue {C498}
cysteine residue {C498}
MODIFICATION: cysteine residue {C482}
cysteine residue {C530}
MODIFICATION: cysteine residue {C543}
cysteine residue {C543}
MODIFICATION: cysteine residue {C530}
cysteine residue {C571}
MODIFICATION: cysteine residue {C591}
cysteine residue {C591}
MODIFICATION: cysteine residue {C571}
Database Correlations
UniProt Q6P9A2
PFAM correlations
Entrez Gene 374378
Kegg hsa:374378
ENZYME 2.4.1.41
References
- UniProt :accession Q6P9A2
- GGDB, GlycoGene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp