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polyomavirus middle T antigen (PVMT)

PVMT binds to c-src protein Tyr-527 & prevents phosphorylation. It activates c-src protein & itself becomes phosphorylated on Tyr-315 & Tyr-250. PVMT also binds to grb2 & shc & perhaps Sos, PI-3-kinase & 14-3-3 (4).

Interactions

molecular events

General

polyomavirus T antigen

Properties

SIZE: MW = 58 kD COMPARTMENT: plasma membrane MOTIF: binding site SITE: N-TERMINAL FOR-BINDING-OF: src proto-oncogene protein Tyr phosphorylation site {Y250} Tyr phosphorylation site {Y315}

References

  1. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: 1988147
  2. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: 1846320
  3. Dilworth SM, Brewster CE, Jones MD, Lanfrancone L, Pelicci G, Pelicci PG. Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature. 1994 Jan 6;367(6458):87-90. PMID: 7509037
  4. Aitken A. 14-3-3 proteins on the MAP. Trends Biochem Sci. 1995 Mar;20(3):95-7. PMID: 7709434

Component-of

molecular complex