polymerase delta interacting protein 3; 46 kD DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR (POLDIP3 KIAA1649 PDIP46)

Function: - role in regulation of translation - preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation - contributes to enhanced translational efficiency of spliced over nonspliced mRNAs - recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA - phosphorylated upon DNA damage, probably by ATM or ATR - phosphorylated at Ser-383 & Ser-385 by RPS6KB1 - interacts with POLD2 - interacts with NCBP1 & EIF4A3 - associates with the multiprotein exon junction complex (EJC) - interacts with RPS6KB1 (activated). interacts with ERH Structure: contains 1 RRM domain (RNA recognition motif) Compartment: - nucleus, nuclear speckle, cytoplasm - nucleocytoplasmic shuttling protein Alternative splicing: named isoforms=2

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 421 aa MW = 46 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S42} Ser phosphorylation site {S127} Thr phosphorylation site {T140} Ser phosphorylation site {S275} RNP motif NAME: RNP motif SITE: 280-351 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S383} Ser phosphorylation site {S385}

Database Correlations

OMIM 611520 UniProt Q9BY77 Pfam PF00076 Entrez Gene 84271 Kegg hsa:84271

References

UniProt :accession Q9BY77