polyhomeotic-like protein 2 (hPH2, early development regulatory protein 2, PHC2, EDR2, PH2)

Function: - component of PRC1 complex - interacts with N-terminal region of SP1 transcription factor & with MAPKAPK2 Structure: - HD1 motif interacts with SAM domain of PHC1 - contains 1 FCS-type zinc finger contains 1 SAM domain (sterile alpha motif) Compartment: nucleus Alternative splicing: named isoforms=3

General

nuclear protein phosphoprotein protein subunit zinc finger protein

Properties

SIZE: MW = 91 kD entity length = 858 aa COMPARTMENT: cell nucleus MOTIF: serine-rich region {11-37} MOTIF: serine residue (SEVERAL) glutamine-rich region {55-111} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {329-377} MOTIF: glutamine residue (SEVERAL) HD1 {558-587} Zinc finger NAME: Zinc finger SITE: 633-667 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S745} sterile alpha motif NAME: sterile alpha motif SITE: 794-858

Database Correlations

OMIM 602979 UniProt Q8IXK0 Pfam PF00536

References

UniProt :accession Q8IXK0