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polycystic kidney disease protein 1-like 3 (polycystin-1L3, PC1-like 3 protein, PKD1L3)
Function:
- may function as an ion-channel regulator
- may function with PKD2L1 as heteromeric taste channels (putative)
Structure:
- belongs to the polycystin family
- contains 1 C-type lectin domain
- contains 1 GPS domain
- contains 1 PLAT domain
Compartment: membrane (putative)
Expression: highly expressed in placenta, weakly in heart & lung
General
glycoprotein
transmembrane 12e protein
Properties
SIZE: entity length = 1732 aa
MW = 196 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-697}
MOTIF: signal sequence {1-23}
C-type lectin {30-138}
cysteine residue {C51}
MODIFICATION: cysteine residue {C137}
cysteine residue {C112}
MODIFICATION: cysteine residue {C129}
cysteine residue {C129}
MODIFICATION: cysteine residue {C112}
cysteine residue {C137}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N286}
N-glycosylation site {N363}
N-glycosylation site {N515}
N-glycosylation site {N537}
N-glycosylation site {N575}
GPS {632-681}
transmembrane domain {698-718}
cytoplasmic loop {719-905}
MOTIF: PLAT {743-860}
transmembrane domain {906-926}
exoplasmic loop {927-939}
transmembrane domain {940-960}
cytoplasmic loop {961-1154}
transmembrane domain {1155-1175}
exoplasmic loop {1176-1198}
transmembrane domain {1199-1219}
cytoplasmic loop {1220-1280}
MOTIF: lysine-rich region {1274-1277}
MOTIF: lysine residue (SEVERAL)
transmembrane domain {1281-1301}
exoplasmic loop {1302-1462}
transmembrane domain {1463-1483}
cytoplasmic loop {1484-1501}
transmembrane domain {1502-1522}
exoplasmic loop {1523-1550}
transmembrane domain {1551-1571}
cytoplasmic loop {1572-1592}
transmembrane domain {1593-1613}
exoplasmic loop {1614-1625}
MOTIF: Channel pore-region {1613-1625}
transmembrane domain {1626-1646}
MOTIF: Channel pore-region {1626-1646}
cytoplasmic loop {1647-1658}
MOTIF: Channel pore-region {1647-1651}
transmembrane domain {1659-1679}
exoplasmic domain {1680-1732}
Database Correlations
OMIM 607895
UniProt Q7Z443
PFAM correlations
Kegg hsa:3423
References
UniProt :accession Q7Z443