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polycystic kidney disease protein 1-like 2 (polycystin-1L2, PC1-like 2 protein, PKD1L2, KIAA1879, PC1L2)
Function:
- may function as an ion-channel regulator
- may function as a G-protein-coupled receptor
- may interact via its C-terminus with GNAS & GNAI1
Structure:
- belongs to the polycystin family
- contains 1 C-type lectin domain
- contains 1 GPS domain
- contains 1 PLAT domain contains 1 REJ domain contains 1 SUEL-type lectin domain
Compartment: membrane (putative)
Alternative splicing: named isoforms=7
Expression:
- expressed in all tissues tested including brain, placenta, mammary gland, testis, lung & liver.
- highest expression in skeletal muscle
- isoform 2 is expressed in heart & kidney
- expressed in fetal heart
General
glycoprotein
transmembrane 12e protein
Properties
SIZE: entity length = 2459 aa
MW = 273 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-1344}
MOTIF: signal sequence {1-17}
C-type lectin {35-153}
cysteine residue {C56}
MODIFICATION: cysteine residue {C152}
N-glycosylation site {N96}
N-glycosylation site {N110}
cysteine residue {C128}
MODIFICATION: cysteine residue {C144}
cysteine residue {C144}
MODIFICATION: cysteine residue {C128}
cysteine residue {C152}
MODIFICATION: cysteine residue {C56}
SUEL-type lectin {161-252}
N-glycosylation site {N268}
N-glycosylation site {N307}
J domain {422-1123}
N-glycosylation site {N441}
N-glycosylation site {N536}
N-glycosylation site {N1176}
N-glycosylation site {N1186}
GPS {1279-1328}
transmembrane domain {1345-1365}
cytoplasmic loop {1366-1552}
MOTIF: PLAT {1390-1507}
transmembrane domain {1553-1573}
exoplasmic loop {1574-1594}
transmembrane domain {1595-1615}
cytoplasmic loop {1616-1818}
transmembrane domain {1819-1839}
exoplasmic loop {1840-1865}
transmembrane domain {1866-1886}
cytoplasmic loop {1887-1943}
transmembrane domain {1944-1964}
exoplasmic loop {1965-2143}
MOTIF: Polycystin {2024-2035}
Polycystin {2119-2129}
transmembrane domain {2144-2166}
cytoplasmic loop {2167-2182}
transmembrane domain {2183-2203}
exoplasmic loop {2204-2218}
transmembrane domain {2219-2239}
cytoplasmic loop {2240-2270}
transmembrane domain {2271-2291}
exoplasmic loop {2292-2312}
transmembrane domain {2313-2333}
cytoplasmic loop {2334-2377}
MOTIF: Channel pore-region {2340-2362}
transmembrane domain {2378-2398}
exoplasmic domain {2399-2459}
MOTIF: GNAS & GNAI1 interaction {2379-2459}
Database Correlations
OMIM 607894
UniProt Q7Z442
PFAM correlations
References
UniProt :accession Q7Z442