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polycystic kidney disease & receptor for egg jelly-related protein (PKD & REJ homolog, PKDREJ)
Function:
1) role in fertilization
2) may generate a Ca+2 transporting channel directly involved in initiating the acrosome reaction of the sperm
3) may form homomultimers or heteromultimers in combination with unidentified subunits
Structure:
- belongs to the polycystin family
- contains 1 PLAT domain
- contains 1 REJ domain
Compartment: membrane
Expression:
- exclusively expressed in testis
General
glycoprotein
testis-specific protein
transmembrane 11e protein
Properties
SIZE: MW = 255 kD
entity length = 2253 aa
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: testis
MOTIF: signal sequence {1-19}
exoplasmic domain {20-1184}
MOTIF: N-glycosylation site {N197}
J domain {215-913}
N-glycosylation site {N242}
N-glycosylation site {N295}
N-glycosylation site {N306}
N-glycosylation site {N345}
N-glycosylation site {N349}
N-glycosylation site {N481}
N-glycosylation site {N674}
N-glycosylation site {N849}
N-glycosylation site {N890}
N-glycosylation site {N923}
N-glycosylation site {N939}
N-glycosylation site {N958}
N-glycosylation site {N965}
transmembrane domain {1185-1205}
cytoplasmic loop {1206-1389}
MOTIF: PLAT {1230-1347}
transmembrane domain {1390-1410}
exoplasmic loop {1411-1427}
transmembrane domain {1428-1448}
cytoplasmic loop {1449-1576}
transmembrane domain {1577-1597}
exoplasmic loop {1598-1607}
transmembrane domain {1608-1628}
cytoplasmic loop {1629-1708}
transmembrane domain {1709-1729}
exoplasmic loop {1730-1966}
MOTIF: N-glycosylation site {N1836}
N-glycosylation site {N1893}
N-glycosylation site {N1944}
transmembrane domain {1967-1987}
cytoplasmic loop {1988-1996}
transmembrane domain {1997-2017}
exoplasmic loop {2018-2042}
transmembrane domain {2043-2063}
cytoplasmic loop {2064-2091}
transmembrane domain {2092-2112}
exoplasmic loop {2113-2145}
transmembrane domain {2146-2166}
cytoplasmic domain {2167-2253}
Database Correlations
OMIM 604670
UniProt Q9NTG1
PFAM correlations
References
UniProt :accession Q9NTG1