polycomb repressive complex 1-like

Function: - E3 ubiquitin ligase activity Structure: - consists of: PHC2, PCGF4, RING1 & RNF2

Properties

SUBUNITS: polyhomeotic-like protein 2 COMPARTMENT: cell nucleus MOTIF: serine-rich region {11-37} MOTIF: serine residue (SEVERAL) glutamine-rich region {55-111} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {329-377} MOTIF: glutamine residue (SEVERAL) HD1 {558-587} Zinc finger NAME: Zinc finger SITE: 633-667 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S745} sterile alpha motif NAME: sterile alpha motif SITE: 794-858 polycomb complex protein BMI-1 COMPARTMENT: cytoplasm cell nucleus MOTIF: RING-finger {18-57} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif nuclear translocation signal {81-95} E4F1 interaction {164-228} serine-rich region {251-326} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S251} Ser phosphorylation site {S253} Ser phosphorylation site {S255} E3 ubiquitin-protein ligase RING1 COMPARTMENT: cell nucleus MOTIF: silencer element SITE: 30-234 MOTIF: Ser phosphorylation site {S38} RING-finger {48-88} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Ser phosphorylation site {S187} Ser phosphorylation site {S188} Ser phosphorylation site {S190} nuclear translocation signal {201-204} glycine-rich region {205-260} CBX2 interaction {230-406} MOTIF: glycine-rich region {314-377} E3 ubiquitin-protein ligase RING2 COMPARTMENT: cell nucleus MOTIF: HIP2 interaction {1-179} MOTIF: RING-finger {51-91} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Ser phosphorylation site {S168} Ser phosphorylation site {S203}

References

UniProt :accession P78364

Components

E3 ubiquitin-protein ligase RING1; RING finger protein 1; polycomb complex protein RING1 (RING1, RNF1) E3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; HIP2-interacting protein 3; protein DinG; RING finger protein 1B; RING1b; RING finger protein 2; RING finger protein BAP-1 (RNF2, BAP1, DING, HIPI3, RING1B) polycomb complex protein BMI-1; polycomb group RING finger protein 4; RING finger protein 51 (BMI1, PCGF4, RNF51) polyhomeotic-like protein 2 (hPH2, early development regulatory protein 2, PHC2, EDR2, PH2)