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polycomb group protein ASXL2 (ddditional sex combs-like protein 2, ASXL2, ASXH2, KIAA1685)
Function:
- putative polycomb group (PcG) protein
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors
- belongs to the Asx family
- contains 1 PHD-type Zn+2 finger
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
Pathology:
- chromosomal translocation t(2;8)(p23;p11.2 involving ASXL2 with MYST3 is a cause of therapy-related myelodysplastic syndrome
- the translocation generates a MYST3-ASXL2 fusion protein
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 1435 aa
MW = 154 kD
COMPARTMENT: cell nucleus
MOTIF: breakpoint {20-21}
serine-rich region {95-235}
MOTIF: serine residue (SEVERAL)
nuclear translocation signal {174-178}
LXXLL motif 1 {303-307}
Ser phosphorylation site {S517}
alanine-rich region {654-684}
MOTIF: alanine residue (SEVERAL)
glycine-rich region {687-739}
Ser phosphorylation site {S834}
Ser phosphorylation site {S845}
LXXLL motif 2 {887-891}
serine-rich region {1173-1176}
MOTIF: serine residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1397-1434
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt Q76L83
References
UniProt :accession Q76L83