polyamine-modulated factor 1 (PMF-1, PMF1)

Function: - component of MIS12 complex - may act as a cotranscription partner of NFE2L2 with role in regulation of polyamine-induced transcription of SSAT - interacts with COPS7A - interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2 - interaction with NFE2L2 is required for the transcriptional regulation of SSAT Compartment: nucleus, kinetochore Alternative splicing: named isoforms=5 Expression: - expression in heart & skeletal muscle > kidney & liver -induced by polyamine analogs in analog-sensitive H157 cells

General

kinetochore protein nuclear protein

Properties

SIZE: MW = 23 kD entity length = 205 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {141-193}

Database Correlations

UniProt Q6P1K2 Pfam PF03980

References

UniProt :accession Q6P1K2