polyadenylate-binding protein 4; poly(A)-binding protein 4; PABP 4; inducible poly(A)-binding protein; iPABP; activated-platelet protein 1; APP-1 (PABPC4, APP1, PABP4)

Function: - binds the poly(A) tail of mRNA. may be involved in cytoplasmic regulatory processes of mRNA metabolism - can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo - interacts with NFX1 Structure: - Arg-518 is dimethylated, probably to asymmetric dimethylarginine - belongs to the polyadenylate-binding protein type-1 family - contains 1 PABC domain - contains 4 RRM domain (RNA recognition motif)s Compartment: cytoplasm Alternative splicing: named isoforms=2 Expression: - expressed at low levels in resting normal T cells - following T-cell activation, however, mRNA levels are rapidly up-regulated

General

phosphoprotein polyadenylate binding protein

Properties

SIZE: entity length = 644 aa MW = 71 kD COMPARTMENT: cytoplasm MOTIF: RNP motif NAME: RNP motif SITE: 11-89 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Tyr phosphorylation site {Y54} Ser phosphorylation site {S96} RNP motif NAME: RNP motif SITE: 99-175 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Tyr phosphorylation site {Y140} RNP motif NAME: RNP motif SITE: 191-268 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 294-370 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif alanine-rich region {510-516} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S531} PABC {551-628}

Database Correlations

OMIM 603407 UniProt Q13310 PFAM correlations Entrez Gene 8761

References

UniProt :accession Q13310