podocan (PODN)

Function: - binds to type 1 collagen Structure: - N-glycosylated - belongs to the small leucine-rich proteoglycan (SLRP) family, class V subfamily. - contains 20 LRR repeats (leucine-rich repeats) Compartment: extracellular matrix Alternative splicing: named isoforms=2 Expression: - kidney, heart, liver, pancreas, vascular smooth muscle cells Distinguish from podocin

General

glycoprotein matrix protein

Properties

SIZE: MW = 69 kD entity length = 613 aa COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-19} leucine-rich repeat SITE: 94-118 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 119-144 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 146-168 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 190-215 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N214} leucine-rich repeat SITE: 217-237 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 238-260 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 262-286 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N281} leucine-rich repeat SITE: 287-310 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 312-331 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 332-357 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 358-381 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 383-402 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 403-428 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N410} leucine-rich repeat SITE: 429-452 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 454-473 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 474-499 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 500-523 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 525-544 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 546-570 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 571-597 MOTIF: leucine residue (SEVERAL) glutamate-rich region {598-611} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 608661 UniProt Q7Z5L7 PFAM correlations

References

UniProt :accession Q7Z5L7