podocalyxin-like protein 2 (endoglycan, PODXL2)

Function: - binds to SELL/L-selectin Structure: - belongs to the podocalyxin family - homodimer. disulfide-linked - glycosylated, contains chondroitin sulfate - displays sialylated O-linked oligosaccharides - sulfation & sialylated O-linked oligosaccharides are necessary for SELL/L-selectin binding Compartment: membrane Alternative splicing: named isoforms=2 Expression: - expressed in brain > pancreas, kidney & lymphoid node > liver - detected in both endothelial cells & CD34+ bone marrow cells

General

glycoprotein membrane protein phosphoprotein

Properties

SIZE: MW = 65 kD entity length = 605 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-32} glutamate-rich region {162-198} MOTIF: glutamate residue (SEVERAL) N-glycosylation site {N193} N-glycosylation site {N395} transmembrane domain {501-521} Ser phosphorylation site {S596}

Database Correlations

UniProt Q9NZ53 Pfam PF06365

References

UniProt :accession Q9NZ53