melanocyte protein Pmel 17; Silver locus protein homolog; melanocyte lineage-specific antigen GP100; melanoma-associated ME20 antigen; ME20-M; ME20M; contains: ME20-S; secreted melanoma-associated ME20 antigen; ME20S; 95 kD melanocyte-specific secreted glycoprotein (SILV, D12S53E, PMEL17)

Function: - may be a melanogenic enzyme - may represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes & during tumor growth - release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity Structure: - belongs to the Pmel-17/NMB family - contains 1 PKD domain Compartment: - membrane; single-pass type 1 membrane protein (putative) - melanosome, from stage 1 to stage 4 - ME20-S: secreted (probable); probably product of proteolytic cleavage Expression: - preferentially expressed in melanomas - some expression was found in dysplastic nevi - not found in normal tissues nor in carcinomas Laboratory: - Human Melanoma Black (HMB)-45 Ag in tissue

General

glycoprotein membrane protein

Properties

SIZE: entity length = 661 aa MW = 70 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-24} N-glycosylation site {N81} N-glycosylation site {N106} N-glycosylation site {N111} PKD {255-292} repeats {315-444} MOTIF: consensus repeat {315-327} N-glycosylation site {N321} consensus repeat {328-340} consensus repeat {341-353} consensus repeat {354-366} consensus repeat {367-379} consensus repeat {380-392} consensus repeat {393-405} consensus repeat {406-418} consensus repeat {419-431} consensus repeat {432-444} N-glycosylation site {N568} transmembrane domain {596-616}

Database Correlations

OMIM 155550 UniProt P40967 Pfam PF00801 Entrez Gene 6490 Kegg hsa:6490

References

UniProt :accession P40967