PlyG (recombinant gamma-lysin)

lysin derived from bacteriophage gamma Indications: 1) treatment of anthrax (investigational) 2) identification of germinating anthrax spores* * PlyG attached to luciferin detects germinating anthrax spores using a hand-held luminometer Mechanism of action: 1) bactericidal for anthrax in vitro & in vivo -> highly effective in killing B. anthracis, both vegetative cells & germinating spores 2) non toxic in (to) mice 3) mutations in anthrax strains resulting in antibiotic resistance did NOT affect activity of PlyG

General

bacteriophage lysin recombinant protein; chimer

Properties

MOTIF: active site

References

Journal Watch 22(19):152, 2002 Schuch et al. Nature 418:884-9, 2002