Search
plexin domain-containing protein 1 (tumor endothelial marker 7, tumor endothelial marker 3, PLXDC1, TEM3, TEM7)
Function:
- may interact with cortactin
Structure:
- N-glycosylated
- belongs to the plexin family
Compartment:
- isoform 1: membrane
- isoforms 2 & 3: secreted
- isoform 4: cytoplasm
Alternative splicing: named isoforms=4
Expression:
- not detectable in endothelial cells from normal tissue
- detected in endothelial cells from colorectal cancer, & in endothelial cells from primary cancers of the lung, liver, pancreas, breast & brain
General
glycoprotein
membrane protein
secreted protein
tumor endothelial marker
Properties
SIZE: MW = 56 kD
entity length = 500 aa
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-18}
N-glycosylation site {N80}
N-glycosylation site {N197}
transmembrane domain {427-447}
Database Correlations
OMIM 606826
UniProt Q8IUK5
Pfam PF01437
References
UniProt :accession Q8IUK5