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plexin-D1 (PLXND1, KIAA0620)
Structure:
- belongs to the plexin family
- contains 3 IPT/TIG domains
- contains 1 Sema domain
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus & liver
- detected at very low levels in brain, colon, spleen, small intestine & peripheral blood leukocytes
General
glycoprotein
plexin
Properties
SIZE: entity length = 1925 aa
MW = 212 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-46}
Sema {47-546}
MOTIF: N-glycosylation site {N86}
N-glycosylation site {N155}
N-glycosylation site {N188}
N-glycosylation site {N224}
N-glycosylation site {N481}
N-glycosylation site {N500}
N-glycosylation site {N583}
N-glycosylation site {N696}
N-glycosylation site {N736}
N-glycosylation site {N802}
IPT/TIG 1 {891-979}
MOTIF: N-glycosylation site {N965}
IPT/TIG 2 {981-1066}
MOTIF: N-glycosylation site {N1017}
N-glycosylation site {N1060}
IPT/TIG 3 {1069-1160}
MOTIF: N-glycosylation site {N1099}
N-glycosylation site {N1118}
N-glycosylation site {N1132}
N-glycosylation site {N1237}
N-glycosylation site {N1257}
transmembrane domain {1272-1292}
Database Correlations
OMIM 604282
UniProt Q9Y4D7
PFAM correlations
Entrez Gene 23129
References
UniProt :accession Q9Y4D7