plexin-B2; MM1 (PLXNB2 KIAA0315)

Function: - receptor for SEMA4D - plays a role in RHOA activation & subsequent changes of the actin cytoskeleton - plays a role in axon guidance, invasive growth & cell migration - binds c-MET, ARHGEF11 & ARHGEF12 - may also interact with MST1R Structure: - monomer, & heterodimer with PLXNB1 - belongs to the plexin family - contains 3 IPT/TIG domains - contains 1 Sema domain Compartment: membrane

General

glycoprotein plexin B

Properties

SIZE: entity length = 1838 aa MW = 205 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} Sema {20-466} MOTIF: N-glycosylation site {N127} N-glycosylation site {N242} N-glycosylation site {N391} N-glycosylation site {N402} N-glycosylation site {N528} N-glycosylation site {N733} N-glycosylation site {N759} N-glycosylation site {N795} IPT/TIG 1 {803-893} MOTIF: N-glycosylation site {N844} IPT/TIG 2 {895-980} IPT/TIG 3 {983-1092} MOTIF: N-glycosylation site {N1002} N-glycosylation site {N1049} N-glycosylation site {N1068} N-glycosylation site {N1099} peptide motif {1164-1165} transmembrane domain {1198-1218}

Database Correlations

OMIM 604293 UniProt O15031 PFAM correlations Entrez Gene 23654 Kegg hsa:2365

References

UniProt :accession O15031