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plexin-A2; Semaphorin receptor OCT (PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235)
Function:
1) coreceptor for SEMA3A
2) signaling by class 3 semaphorins*
3) remodelling of cytoskeleton
4) axon guidance
5) invasive growth
6) cell migration
7) interacts with NRP1, NRP2
* class 3 semaphorins bind to a complex composed of a neuropilin & a plexin. The plexin modulates affinity of the complex for specific semaphorins
Structure:
- belongs to the plexin family
- contains 4 IPT/TIG domains
- contains 1 Sema domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: detected in fetal brain
General
glycoprotein
phosphoprotein
plexin A
Properties
SIZE: MW = 213 kD
entity length = 1909 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-49}
SEMA {50-523}
MOTIF: N-glycosylation site {N91}
N-glycosylation site {N106}
N-glycosylation site {N342}
N-glycosylation site {N613}
N-glycosylation site {N711}
N-glycosylation site {N771}
IPT/TIG 1 {873-967}
IPT/TIG 2 {969-1053}
IPT/TIG 3 {1056-1155}
IPT/TIG 4 {1158-1251}
MOTIF: N-glycosylation site {N1220}
transmembrane domain {1253-1273}
coiled coil {1276-1325}
Ser phosphorylation site {S1645}
Ser phosphorylation site {S1648}
Database Correlations
OMIM 601054
UniProt O75051
PFAM correlations
Entrez Gene 5362
Kegg hsa:5362
References
UniProt :accession O75051