Search
plexin-A1; semaphorin receptor NOV (PLXNA1, NOV, PLXN1)
Function:
1) coreceptor for SEMA3A, SEMA3C, SEMA3F & SEMA6D.
2) signaling by class 3 semaphorins*
3) remodelling of cytoskeleton
4) axon guidance
5) invasive growth
6) cell migration
7) interacts with NRP1, NRP2, FARP2, RND1, VEGFR2
8) binding of SEMA3A leads to dissociation of FARP2
* class 3 semaphorins bind to a complex composed of a neuropilin & a plexin; the plexin modulates affinity of the complex for specific semaphorins
Structure:
- belongs to the plexin family
- contains 4 IPT/TIG domains
- contains 1 Sema domain
Compartment: membrane
Expression: expressed in fetal brain, lung, liver, kidney.
Interactions
molecular events
General
glycoprotein
plexin A
Properties
SIZE: MW = 211 kD
entity length = 1896 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
SEMA {27-512}
MOTIF: N-glycosylation site {N77}
N-glycosylation site {N660}
N-glycosylation site {N672}
N-glycosylation site {N701}
IPT/TIG 1 {864-959}
IPT/TIG 2 {961-1045}
MOTIF: N-glycosylation site {N1043}
IPT/TIG 3 {1048-1147}
IPT/TIG 4 {1150-1236}
MOTIF: N-glycosylation site {N1187}
N-glycosylation site {N1212}
transmembrane domain {1245-1265}
coiled coil {1264-1317}
Database Correlations
OMIM 601055
UniProt Q9UIW2
PFAM correlations
Entrez Gene 5361
Kegg hsa:5361
References
UniProt :accession Q9UIW2
Component-of
molecular complex