Search
pleiotrophin; PTN; heparin-binding brain mitogen; HBBM; heparin-binding growth factor 8; HBGF-8; heparin-binding growth-associated molecule; HB-GAM; heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; osteoblast-specific factor 1; OSF-1 (PTN HBNF1 NEGF1)
Function:
- secreted growth factor
- induces neurite outgrowth
- mitogenic for fibroblasts, epithelial, & endothelial cells
- binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN & regulation of cell proliferation
- phosphorylated by NEK6
- interacts with ALK & NEK6
Structure: belongs to the pleiotrophin family
Compartment: secreted
Expression:
- expressed in osteoblasts & in brain
- induced by heparin & retinoic acid
General
growth factor
secreted protein
Properties
SIZE: entity length = 168 aa
MW = 19 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-32}
cysteine residue {C47}
MODIFICATION: cysteine residue {C76}
cysteine residue {C55}
MODIFICATION: cysteine residue {C85}
cysteine residue {C62}
MODIFICATION: cysteine residue {C89}
cysteine residue {C76}
MODIFICATION: cysteine residue {C47}
cysteine residue {C85}
MODIFICATION: cysteine residue {C55}
cysteine residue {C89}
MODIFICATION: cysteine residue {C62}
cysteine residue {C99}
MODIFICATION: cysteine residue {C131}
cysteine residue {C109}
MODIFICATION: cysteine residue {C141}
cysteine residue {C131}
MODIFICATION: cysteine residue {C99}
cysteine residue {C141}
MODIFICATION: cysteine residue {C109}
Database Correlations
OMIM 162095
UniProt P21246
PFAM correlations
Entrez Gene 5764
Kegg hsa:5764
References
- UniProt :accession P21246
- Wikipedia; Note: pleiotrophin entry
http://en.wikipedia.org/wiki/pleiotrophin
- Ruoslahti E, Yamaguchi Y.
Proteoglycans as modulators of growth factor activities.
Cell. 1991 Mar 8;64(5):867-9. Review.
PMID: 2001586