pleckstrin homology domain-containing family M member 1 (162 kD adapter protein, AP162, PLEKHM1, KIAA0356)

Function: - appears to be implicated in the development of osteopetrosis (diminished bone resorption) with a function in vesicular transport in the osteoclast - may have a role in sialyl-lex-mediated transduction of apoptotic signals - in colon carcinoma & breast carcinoma cells, it interacts with sialyl-lex-positive protein Structure: - contains 2 PH domains - contains 1 phorbol-ester/DAG-type zinc finger - contains 1 RUN domain Compartment: cytoplasm (putative) Expression: - expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma & peripheral blood lymphocytes - weakly expressed in brain, lung, kidney, & testis - no expression in heart, skeletal muscle, pancreas & small intestine Pathology: - expressed in the breast carcinoma cell line MCF-7 Miscellaneous: sialyl-lex is a carcinoma associated antigen

General

phosphoprotein pleckstrin homology domain containing family

Properties

SIZE: entity length = 1056 aa MW = 117 kD COMPARTMENT: cytoplasm MOTIF: RUN {41-183} Ser phosphorylation site {S435} PH domain {534-625} PH domain {683-777} Zinc finger NAME: Zinc finger SITE: 986-1040 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q9Y4G2 PFAM correlations

References

UniProt :accession Q9Y4G2