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pleckstrin homology domain-containing family K member 1 (rhotekin-2, PLEKHK1, RTKN2)
Function:
- may play an important role in lymphopoiesis
Structure: contains 1 PH domain
Alternative splicing: named isoforms=3
Expression:
- expressed in lymphocytes, CD4 positive T-cells & bone marrow-derived cells
- also expressed in lung, colon, thymus & brain
- up-regulated in cells resistant to 25-hydroxycholesterol
General
pleckstrin homology domain containing family
Properties
SIZE: entity length = 609 aa
MW = 69 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {56-91}
PH domain {286-393}
Database Correlations
UniProt Q8IZC4
Pfam PF00169
References
UniProt :accession Q8IZC4