pleckstrin homology domain-containing family B member 1; PH domain-containing family B member 1; evectin-1; PH domain-containing protein in retina 1; PHRET1; pleckstrin homology domain retinal protein 1 (PLEKHB1, EVT1, KPL1, PHR1, PHRET1)

Function: - required for proper localization of retina-geniculate projections but not for eye-specific segregation (putative) - homodimer - interacts (via PH domain) with MYO1C - interacts (via PH domain) with MYO7A (putative) - binds transducins Structure: contains 1 PH domain Compartment: - membrane. cytoplasm (putative) - localizes to the apical juxta-nuclear Golgi region of the cytoplasm (putative) - membrane-associated - highly expressed in the outer segments of photoreceptor cells, both in rods & cones Alternative splicing: named isoforms=4 Expression: - highly expressed in retina & brain - levels are very low or not detectable in all other tissues tested

Related

pleckstrin homology [PH] domain pleckstrin; platelet p47 protein (PLEK P47)

Properties

SIZE: entity length = 243 aa MW = 27 kD COMPARTMENT: cytoplasm cell nucleus golgi MOTIF: PH domain {21-128}

Database Correlations

OMIM 607651 UniProt Q9UF11 Entrez Gene 58473 Kegg hsa:58473

References

UniProt :accession Q9UF11