pleckstrin homology domain-containing family A member 8 (phosphoinositol 4-phosphate adapter protein 2, phosphatidylinositol-four-phosphate adapter protein 2, hFAPP2, serologically defined breast cancer antigen NY-BR-86, PLEKHA8, FAPP2)

Function: - role in TGN-to-plasma membrane transport & in the formation of post-Golgi constitutive carriers - may play a role in ensuring the coordination of budding & fission reactions - interacts with phosphatidylinositol-4-phosphate (PIP) & the GTPase ADP-ribosylation factor (ARF) Structure: - contains 1 plekstrin homology domain (PH domain) - interacts with PIP & ARF via plekstrin homology domain Compartment: - cytoplasm - localized to perinuclear structures in the trans-Golgi network (TGN) Alternative splicing: named isoforms=3 Expression: expressed in kidney cell lines

Properties

SIZE: entity length = 519 aa MW = 58 kD COMPARTMENT: cytoplasm MOTIF: PH domain {1-93}

Database Correlations

OMIM 608639 UniProt Q96JA3 PFAM correlations

References

UniProt :accession Q96JA3