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pleckstrin homology domain-containing family A member 7; PH domain-containing family A member 7 (PLEKHA7)
Function:
- required for adherens junction biogenesis & maintenance
- acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to the adherens junction, & recruits KIFC3 kinesin to junctional site
- interacts with KIAA1543/Nezha & CTNND1
Structure:
- contains 1 PH domain
- contains 2 WW domains
Compartment:
- cell junction, adherens junction
- cytoplasm, cytoskeleton, centrosome
- localizes to adherens junction, recruited via its interaction with CTNND1
Alternative splicing: named isoforms=3
General
human longevity protein
phosphoprotein
pleckstrin homology domain containing family
Properties
SIZE: MW = 127 kD
entity length = 1121 aa
COMPARTMENT: cytoplasm
MOTIF: WW domain (W/rsp5/WWP domain) {9-42}
WW domain (W/rsp5/WWP domain) {54-87}
PH domain {164-282}
Ser phosphorylation site {S536}
CTNND1 interaction {538-696}
MOTIF: Ser phosphorylation site {S545}
proline-rich region
SITE: 567-599
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S569}
Ser phosphorylation site {S604}
Ser phosphorylation site {S608}
Ser phosphorylation site {S612}
coiled coil {700-801}
proline-rich region
SITE: 845-942
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S858}
Ser phosphorylation site {S860}
Ser phosphorylation site {S867}
Thr phosphorylation site {T870}
Ser phosphorylation site {S871}
Ser phosphorylation site {S903}
Ser phosphorylation site {S907}
Ser phosphorylation site {S986}
coiled coil {1067-1094}
Database Correlations
OMIM 612686
UniProt Q6IQ23
Pfam PF00169
Entrez Gene 144100
Kegg hsa:144100
References
UniProt :accession Q6IQ23