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pleckstrin; platelet p47 protein (PLEK P47)
Function:
- major substrate of protein kinase C in platelets
- exact function unknown
Structure:
- contains 1 DEP domain
- contains 2 PH domains
Interactions
molecular events
Related
pleckstrin homology [PH] domain
pleckstrin-2 (PLEK2)
General
phosphoprotein
pleckstrin homology domain containing family
Properties
SIZE: entity length = 350 aa
MW = 40 kD
COMPARTMENT: cytoplasm
MOTIF: PH domain {4-101}
Ser phosphorylation site {S113}
Ser phosphorylation site {S117}
DEP domain {136-221}
MOTIF: Ser phosphorylation site {S183}
Ser phosphorylation site {S197}
PH domain {244-347}
Database Correlations
OMIM 173570
UniProt P08567
PFAM correlations
Entrez Gene 5341
Kegg hsa:5341
References
- UniProt :accession P08567
- Musacchio A, Gibson T, Rice P, Thompson J, Saraste M.
The PH domain: a common piece in the structural patchwork of
signalling proteins.
Trends Biochem Sci. 1993 Sep;18(9):343-8. Review.
PMID: 8236453