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platelet-rich plasma therapy

Indications: - tendon injuries (tendonitis) [1] ? - osteoarthritis [1] ? - lower-extremity diabetic ulcers (diabetic foot ulcers)* [2] - lower-extremity venous ulcers* [2] - pressure ulcers* [2] * autologous platelet-rich plasma [2] Contraindications: - no benefit for Achilles tendonitis [3] - no benefit for ankle osteoarthritis [4] or knee osteoarthritis [5]

General

clinical procedure

References

  1. Orthohealing center: Platelet Rich Plasma (PRP) Therapy http://www.orthohealing.com/plateletrichplasmatherapy-prp/
  2. Qu W, Wang Z, Hunt C et al The Effectiveness and Safety of Platelet-Rich Plasma for Chronic Wounds. Mayo Proc 2021. July 3 PMID: 34226023 https://www.mayoclinicproceedings.org/article/S0025-6196(21)00166-X/fulltext
  3. Kearney RS, Ji C, Warwick J et al. Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion Achilles tendinopathy: A randomized clinical trial. JAMA 2021 Jul 13; 326:137 PMID: 34255009 https://jamanetwork.com/journals/jama/article-abstract/2781859
  4. Paget LDA, Reurink G, de Vos RJ et al. Effect of platelet-rich plasma injections vs placebo on ankle symptoms and function in patients with ankle osteoarthritis: A randomized clinical trial. JAMA 2021 Oct 26; 326:1595 PMID: 34698782 https://jamanetwork.com/journals/jama/article-abstract/2785499
  5. Bennell KL et al. Effect of intra-articular platelet-rich plasma vs placebo injection on pain and medial tibial cartilage volume in patients with knee osteoarthritis: The RESTORE randomized clinical trial. JAMA 2021 Nov 23/30; 326:2021. PMID: 34812863 JAMA. 2021;326(20):2021-2030