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platelet glycoprotein 6 (GP6, GPVI)
Function:
1) collagen receptor
2) collagen-induced platelet adhesion & activation
3) platelet procoagulant activity with subsequent thrombin & fibrin formation
4) procoagulant function contributing to arterial & venous thrombus formation
5) signaling pathway involves the FcR gamma-chain, Src kinases (likely Fyn/Lyn), the adapter protein LAT & leads to the activation of phospholipase C gamma2
6) associated with Fc receptor gamma chain
7) GP6-FcRgamma complex is associated with the Src kinase family Fyn & Lyn
Compartment: membrane
Alternative splicing: named isoforms=3 Megakaryocytes & platelets
Pathology:
- deficiency in GP6 results in a mild hemorrhagic diathesis platelets fail to aggregate in response to collagen
General
glycoprotein
Properties
SIZE: MW = 37 kD
entity length = 339 aa
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {26-104}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C88}
cysteine residue {C88}
MODIFICATION: cysteine residue {C48}
N-glycosylation site {N92}
immunoglobulin superfamily domain {114-196}
MOTIF: cysteine residue {C134}
MODIFICATION: cysteine residue {C180}
cysteine residue {C180}
MODIFICATION: cysteine residue {C134}
transmembrane domain {268-288}
Database Correlations
OMIM 605546
UniProt Q9HCN6
Pfam PF00047
References
UniProt :accession Q9HCN6