Search
platelet-derived growth factor receptor-like protein; PDGFR-like protein; PDGF receptor beta-like tumor suppressor (PDGFRL, PRLTS)
Function:
- forms a complex composed of PDGFRL, TNK2 & GRB2
Structure:
- contains 2 Ig-like C2-type domains
Compartment: secreted
Expression: expressed in colon, lung, liver
Pathology:
- defects in PDGFRL are associated with colorectal cancer
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 375 aa
MW = 42 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {62-159}
MOTIF: cysteine residue {C96}
MODIFICATION: cysteine residue {C143}
N-glycosylation site {N132}
cysteine residue {C143}
MODIFICATION: cysteine residue {C96}
N-glycosylation site {N219}
immunoglobulin superfamily domain {272-375}
MOTIF: cysteine residue {C293}
MODIFICATION: cysteine residue {C357}
cysteine residue {C357}
MODIFICATION: cysteine residue {C293}
Database Correlations
OMIM correlations
UniProt Q15198
Pfam PF07679
Entrez Gene 5157
Kegg hsa:5157
References
UniProt :accession Q15198