platelet-activating factor acetylhydrolase 1B (PAF acetylhydrolase 1B, PAFAH1B)

Function: 1) inactivates PAF by removing the acetyl group at the sn-2 position 2) cytosolic PAF-AH 1B is formed of 3 subunits - PAFAH1B1 (alpha) - PAFAH1B2 (beta) - PAFAH1B3 (gamma) 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O 1-alkyl-sn-glycero-3-phosphocholine + acetate Structure: - catalytic activity of the enzyme resides in the beta & gamma subunits - the alpha subunit has regulatory activity. - trimer formation is NOT essential for the catalytic activity

General

hydrolase molecular complex

Properties

MOTIF: active site SUBUNITS: platelet-activating factor acetylhydrolase 1B subunit beta COMPARTMENT: cytoplasm MOTIF: serine residue {S48} aspartate residue {D193} histidine residue {H196} platelet-activating factor acetylhydrolase 1B subunit gamma COMPARTMENT: cytoplasm MOTIF: serine residue {S47} aspartate residue {D192} histidine residue {H195}

References

UniProt :accession P68402

Components

platelet-activating factor acetylhydrolase 1B subunit beta (PAF acetylhydrolase 30 kD subunit, PAF-AH 30 kD subunit, PAF-AH subunit beta, PAFAH subunit beta, PAFAH1B2, PAFAHB) platelet-activating factor acetylhydrolase 1B subunit gamma (PAF acetylhydrolase 29 kD subunit, PAF-AH 29 kD subunit, PAF-AH subunit gamma, PAFAH subunit gamma, PAFAH1B3, PAFAHG)