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plastin-1 (I-plastin, intestine-specific plastin, PLS1)
Function:
1) actin-bundling protein in the absence of Ca+2
2) phosphorylated
Structure:
1) monomer
2) contains 2 actin-binding domains
- contains 4 CH (calponin-homology) domains
- contains 2 EF-hand domains
Compartment: cytoplasm
Expression:
- expressed In small intestine, colon, kidney > lung stomach
General
Ca+2 binding protein
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 70 kD
entity length = 629 aa
COMPARTMENT: cytoplasm
MOTIF: EF hand
SITE: 11-46
EF hand
SITE: 51-86
actin-binding site
SITE: 108-380
FOR-BINDING-OF: F-actin
MOTIF: calponin homology domain
NAME: calponin homology domain
SITE: 122-238
calponin homology domain
NAME: calponin homology domain
SITE: 266-376
actin-binding site
SITE: 381-625
FOR-BINDING-OF: F-actin
MOTIF: CH 3 {395-504}
CH 4 {516-625}
Database Correlations
OMIM 602734
UniProt Q14651
PFAM correlations
References
UniProt :accession Q14651