plastin-3; T-plastin (PLS3)

Function: - actin-bundling protein found in intestinal microvilli, hair cell stereocilia, & fibroblast filopodia - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - monomer - contains 2 actin-binding domains - contains 4 CH (calponin-homology) domains - contains 2 EF-hand domains Compartment: cytoplasm Expression: - expressed in a variety of organs, including muscle, brain, uterus & esophagus

General

Ca+2 binding protein cytoskeletal protein

Properties

SIZE: entity length = 630 aa MW = 71 kD COMPARTMENT: cytoplasm FORM: plastin-3 MOTIF: EF hand SITE: 12-47 MOTIF: Ca+2-binding site SITE: 25-36 EF hand SITE: 52-87 MOTIF: Ca+2-binding site SITE: 65-76 actin-binding site SITE: 109-382 FOR-BINDING-OF: F-actin MOTIF: Thr phosphorylation site {T117} calponin homology domain NAME: calponin homology domain SITE: 123-239 calponin homology domain NAME: calponin homology domain SITE: 267-378 Ser phosphorylation site {S326} actin-binding site SITE: 383-627 FOR-BINDING-OF: F-actin MOTIF: Thr phosphorylation site {T391} CH 3 {397-506} Ser phosphorylation site {S477} Thr phosphorylation site {T492} CH 4 {518-627}

Database Correlations

OMIM 300131 UniProt P13797 PFAM correlations Entrez Gene 5358

References

UniProt :accession P13797