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plastin-2; L-plastin; lymphocyte cytosolic protein 1; LCP-1; LC64P (LCP1 PLS2)
Function:
- actin-binding protein found in intestinal microvilli, hair cell stereocilia, & fibroblast filopodia
- phosphorylated
Structure:
- the N-terminus is blocked
- monomer
- contains 2 actin-binding domains
- contains 4 CH (calponin-homology) domains
- contains 2 EF-hand domains
Compartment: cytoplasm
Expression:
- restricted to spleen & other lymph node-containing organs
- expressed in neutrophils, monocytes, B lymphocytes, & myeloid cells
General
Ca+2 binding protein
cytoskeletal protein
Properties
SIZE: entity length = 627 aa
MW = 70 kD
COMPARTMENT: cytoplasm
FORM: plastin-2
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S5}
Ser phosphorylation site {S7}
EF hand
SITE: 9-44
MOTIF: Ca+2-binding site
SITE: 22-33
Tyr phosphorylation site {Y28}
EF hand
SITE: 49-84
MOTIF: Ca+2-binding site
SITE: 62-73
actin-binding site
SITE: 106-379
FOR-BINDING-OF: F-actin
MOTIF: calponin homology domain
NAME: calponin homology domain
SITE: 120-236
Tyr phosphorylation site {Y124}
calponin homology domain
NAME: calponin homology domain
SITE: 264-375
Tyr phosphorylation site {Y276}
actin-binding site
SITE: 380-624
FOR-BINDING-OF: F-actin
MOTIF: CH-3 {394-503}
CH-4 {515-624}
Database Correlations
OMIM 153430
UniProt P13796
PFAM correlations
Entrez Gene 3936
Kegg hsa:3936
References
- UniProt :accession P13796
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/LCP1ID95.html