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plasmolipin; plasma membrane proteolipid (PLLP, PMLP, TM4SF11)
Function:
- appears to be involved in myelination
- may also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent & K+-selective
Structure:
- hexamer arranged as a trimer of two plasmolipin subunits
- belongs to the MAL family
- contains 1 MARVEL domain extending through all 4 transmembrane domains
Compartment: membrane
General
oligomerizing protein
phosphoprotein
transmembrane 4 protein
Properties
SIZE: entity length = 182 aa
MW = 20 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-35}
MOTIF: Ser phosphorylation site {S14}
transmembrane domain {36-56}
exoplasmic loop {57-68}
transmembrane domain {69-89}
cytoplasmic loop {90-99}
transmembrane domain {100-120}
exoplasmic loop {121-141}
transmembrane domain {142-162}
cytoplasmic domain {163-182}
Database Correlations
OMIM 600340
UniProt Q9Y342
Pfam PF01284
Entrez Gene 51090
Kegg hsa:51090
References
UniProt :accession Q9Y342