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plasminogen deficiency
Classification:
- type 1:
- decreased plasminogen activity in plasma
- decreased plasminogen antigen in plasma
- clinical symptoms
- type 2
- normal or slightly decreased plasminogen antigen in plasma
- asymptomatic
Pathology:
- type 1:
- markedly impaired extracellular fibrinolysis
- chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition & inflammation
Genetics:
- associated with defects in plasminogen
Laboratory:
- decreased serum plasminogen activity
- plasminogen antigen in plasma may be normal or decreased
Clinical manifestations:
- type 1:
- ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa
- type 2: asymptomatic
Related
plasminogen; contains: plasmin heavy chain A; activation peptide; angiostatin; plasmin light chain B (PLG)
General
blood protein disorder
enzyme deficiency
hypercoagulability
genetic disease of the blood/bone marrow
Database Correlations
OMIM 217090
References
OMIM :accession 217090