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plasminogen activator inhibitor 2; PAI-2; monocyte Arg-serpin; placental plasminogen activator inhibitor; Serpin B2; urokinase inhibitor (SERPINB2, PAI2, PLANH2)
Function:
- inhibits urokinase-type plasminogen activator
- monocyte derived PAI-2 is distinct from endothelial cell- derived PAI-1
- the signal sequence is not cleaved
- interacts with PSMB1
Structure: belongs to the serpin family, Ov-serpin subfamily
Compartment: cytoplasm. secreted, extracellular space
Expression:
- produced by monocytes
Related
plasminogen activator
plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)
General
glycoprotein
tissue plasminogen activator inhibitor; tPA inhibitor (TPA-I)
Properties
SIZE: entity length = 415 aa
MW = 47 kD
COMPARTMENT: cytoplasm
MOTIF: cysteine residue {C5}
MODIFICATION: cysteine residue {C405}
N-glycosylation site {N75}
N-glycosylation site {N115}
N-glycosylation site {N339}
peptide motif {380-381}
cysteine residue {C405}
MODIFICATION: cysteine residue {C5}
INHIBITS: serine protease
Database Correlations
OMIM 173390
UniProt P05120
Pfam PF00079
Entrez Gene 5055
Kegg hsa:5055
References
UniProt :accession P05120