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PAI1 RNA-binding protein 1; PAI-RBP1; SERPINE1 mRNA-binding protein 1 (SERBP1, PAIRBP1, CGI-55)
Function:
- may play a role in the regulation of mRNA stability
- binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay
- interacts with CHD3 & TDRD3
Compartment:
- cytoplasm, nucleus, perinuclear region
Alternative splicing:
- named isoforms=4
- at least one isoform may be due to competing acceptor splice site
Expression:
- expressed at high level in the heart, skeletal muscle & kidney
- expressed at low levels in placenta, liver & brain
Related
plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 408 aa
MW = 45 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S25}
Thr phosphorylation site {T61}
Ser phosphorylation site {S85}
Ser phosphorylation site {S197}
Ser phosphorylation site {S203}
Ser phosphorylation site {S221}
Thr phosphorylation site {T232}
Ser phosphorylation site {S234}
Tyr phosphorylation site {Y244}
Ser phosphorylation site {S252}
Thr phosphorylation site {T255}
Ser phosphorylation site {S328}
Ser phosphorylation site {S330}
Ser phosphorylation site {S391}
Ser phosphorylation site {S392}
Ser phosphorylation site {S394}
Database Correlations
OMIM 607378
UniProt Q8NC51
Pfam PF04774
Entrez Gene 26135
Kegg hsa:26135
References
UniProt :accession Q8NC51