plasma glutamate carboxypeptidase (PGCP, CPQ)

Function: - carboxypeptidase - may play an important role in the hydrolysis of circulating peptides Structure: belongs to the peptidase M28 family Compartment: secreted Expression: - mainly detected in blood plasma - abundant in placenta & kidney - present at low level in muscles, liver & skin fibroblasts - not detected in brain or white blood cells (at protein level) Pathology: - up-regulated in the majority of hepatitis C virus-associated hepatocellular carcinoma

General

carboxypeptidase glycoprotein secreted protein

Properties

SIZE: entity length = 472 aa MW = 52 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} N-glycosylation site {N61} N-glycosylation site {N179} Zn+2-binding site SITE: 290-290 Zn+2-binding site SITE: 302-302 glutamate residue {E336} Zn+2-binding site SITE: 337-337 N-glycosylation site {N353} N-glycosylation site {N356} Zn+2-binding site SITE: 364-364 N-glycosylation site {N396} Zn+2-binding site SITE: 434-434

Database Correlations

UniProt Q9Y646 Pfam PF04389

References

UniProt :accession Q9Y646