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plasma factors associated with cognitive function
Plasma contains factors that affect cognitive function
Comparative biology:
- plasma beta2 microglobulin (B2M) negatively regulates age-associated cognitive function in hippocampus of mice [3]
- age-associated increase in B2M in plasma levels in humans & mice [3]
- increased plasma eotaxin may inhibit learning, memory, & neurogenesis during aging in mice [4]
- age-associated increase in eotaxin in plasma levels in humans & mice [4]
- blood of young mice contains substances that reverse aging processes in heart muscle, skeletal muscle, & brain
- one of these substances is GDF11 [1]
References
- Katsimpardi L et al.
Vascular and neurogenic rejuvenation of the aging mouse brain
by young systemic factors.
Science 2014 May 9; 344:630. (http://dx.doi.org/10.1126/science.1251141)
PMID: 24797482
- Villeda SA et al.
Young blood reverses age-related impairments in cognitive
function and synaptic plasticity in mice.
Nat Med 2014 May 4
PMID: 24793238
- Bouchard J, Villeda SA
Aging and brain rejuvenation as systemic events
J Neurochem. 2015 Jan; 132(1): 5-19.
PMID: 25327899
- Smith LK, He Y, Park JS et al
beta2-microglobulin is a systemic pro-aging factor that impairs
cognitive function and neurogenesis.
Nat Med. 2015 Jul 6. doi: 10.1038/nm.3898. [Epub ahead of print]
PMID: 26147761
- Villeda SA et al.
The ageing systemic milieu negatively regulates neurogenesis
and cognitive function.
Nature 2011 Sep; 477:90
PMID: 21886162