plasmalemma vesicle-associated protein (plasmalemma vesicle protein 1, PV-1, fenestrated endothelial-linked structure protein, PLVAP, FELS, PV1)

Function: 1) formation of stomatal & fenestral diaphragms of caveolae 2) microvascular permeability Structure: homodimer Compartment: - cell membrane, caveola, cytoplasm, perinuclear region - found in fenestral & stomatal diaphragms in fenestrated endothelia & transendothelial channels - colocalizes with CAV1 in perinuclear region Expression: - expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver Pathology: - expressed in tumor-associated endothelium

General

glycoprotein membrane protein

Properties

SIZE: MW = 51 kD entity length = 442 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: transmembrane domain {28-48} coiled coil {57-77} N-glycosylation site {N83} N-glycosylation site {N89} N-glycosylation site {N113} N-glycosylation site {N151} coiled coil {202-225} coiled coil {280-387}

Database Correlations

OMIM 607647 UniProt Q9BX97 Pfam PF06637

References

UniProt :accession Q9BX97