plakophilin-3 (PKP3)

Function: - may play a role in junctional plaques Structure: - belongs to the beta-catenin family - contains 8 ARM repeats Compartment: - nucleus, cell junction, desmosome - nuclear & associated with desmosomes Expression: - found in desmosomes of most simple and stratified epithelia - not found in foreskin fibroblasts & various sarcoma-derived cell lines - found in dendritic reticular cells of lymphatic follicles - not found in other non-epithelial desmosome-bearing tissues

General

phosphoprotein plakophilin

Properties

SIZE: entity length = 797 aa MW = 87 kD COMPARTMENT: cell nucleus MOTIF: Tyr phosphorylation site {Y84} Ser phosphorylation site {S115} Tyr phosphorylation site {Y176} Ser phosphorylation site {S180} Tyr phosphorylation site {Y195} Ser phosphorylation site {S238} Ser phosphorylation site {S240} ARM repeat {305-348} MOTIF: Ser phosphorylation site {S313} Ser phosphorylation site {S314} ARM repeat {351-390} MOTIF: Tyr phosphorylation site {Y390} ARM repeat {393-432} ARM repeat {449-487} ARM repeat {491-536} ARM repeat {596-637} ARM repeat {645-684} ARM repeat {689-730}

Database Correlations

OMIM 605561 UniProt Q9Y446 Pfam PF00514 Entrez Gene 11187 Kegg hsa:11187

References

UniProt :accession Q9Y446