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poly(U)-specific endoribonuclease; placental protein 11; PP11; protein endoU; uridylate-specific endoribonuclease (ENDOU)
Function:
- endoribonuclease that cleaves single-stranded RNAs at uridylates & releases products that have 2'-3'-cyclic phosphate termini
Cofactor: Mn+2
Structure:
- monomer (putative)
- belongs to the ENDOU family
- contains 2 SMB (somatomedin-B) domains
- the active SMB domain may have disulfide bond variability
Compartment: secreted (putative)
Alternative splicing: named isoforms=3
Expression:
- placental-specific
- also expressed in various malignant neoplasms
Note:
- originally thought to be a serine protease
General
endoribonuclease
placental protein
secreted protein
Properties
SIZE: entity length = 410 aa
MW = 47 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
SMB 1 {20-62}
MOTIF: cysteine residue {C24}
MODIFICATION: cysteine residue {C40}
cysteine residue {C24}
MODIFICATION: cysteine residue {C28}
cysteine residue {C28}
MODIFICATION: cysteine residue {C24}
cysteine residue {C28}
MODIFICATION: cysteine residue {C58}
cysteine residue {C38}
MODIFICATION: cysteine residue {C51}
cysteine residue {C38}
MODIFICATION: cysteine residue {C40}
cysteine residue {C40}
MODIFICATION: cysteine residue {C24}
cysteine residue {C40}
MODIFICATION: cysteine residue {C38}
cysteine residue {C44}
MODIFICATION: cysteine residue {C50}
cysteine residue {C50}
MODIFICATION: cysteine residue {C44}
cysteine residue {C51}
MODIFICATION: cysteine residue {C38}
cysteine residue {C51}
MODIFICATION: cysteine residue {C58}
cysteine residue {C58}
MODIFICATION: cysteine residue {C28}
cysteine residue {C58}
MODIFICATION: cysteine residue {C51}
SMB 2 {86-130}
MOTIF: cysteine residue {C90}
MODIFICATION: cysteine residue {C106}
cysteine residue {C90}
MODIFICATION: cysteine residue {C94}
cysteine residue {C94}
MODIFICATION: cysteine residue {C90}
cysteine residue {C94}
MODIFICATION: cysteine residue {C124}
cysteine residue {C104}
MODIFICATION: cysteine residue {C117}
cysteine residue {C104}
MODIFICATION: cysteine residue {C106}
cysteine residue {C106}
MODIFICATION: cysteine residue {C90}
cysteine residue {C106}
MODIFICATION: cysteine residue {C104}
cysteine residue {C110}
MODIFICATION: cysteine residue {C116}
cysteine residue {C116}
MODIFICATION: cysteine residue {C110}
cysteine residue {C117}
MODIFICATION: cysteine residue {C104}
cysteine residue {C117}
MODIFICATION: cysteine residue {C124}
cysteine residue {C124}
MODIFICATION: cysteine residue {C94}
cysteine residue {C124}
MODIFICATION: cysteine residue {C117}
Database Correlations
OMIM 606720
UniProt P21128
PFAM correlations
Entrez Gene 8909
Kegg hsa:8909
References
UniProt :accession P21128