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phosphatidylinositol [PI] glycan-specific phospholipase D1 (glycoprotein phospholipase D1, glycosyl-phosphatidylinositol specific phospholipase D1, GPLD1, PIGPLD1)
Function:
- hydrolyzes inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane
- hydrolysis of PI glycan occurs intracellularly
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O
6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate
Structure: contains 4 FG-GAP repeats
Expression:
- liver
- plasma Gpld1 higher in physically active than sedentary humans [3]
Compartment: secreted
Alternative splicing: named isoforms=2
Comparative biology:
- Gpld1 increases in mouse plasma after exercise [3]
- enhanced liver production of Gpld1 improves neurogenesis & cognition in mice [3]
General
glycoprotein
phospholipase-D (PLD)
plasma protein
Properties
SIZE: entity length = 840 aa
MW = 92 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-23}
N-glycosylation site {N94}
N-glycosylation site {N271}
N-glycosylation site {N292}
N-glycosylation site {N307}
N-glycosylation site {N321}
FG-GAP {381-419}
FG-GAP {450-488}
N-glycosylation site {N501}
FG-GAP {513-550}
N-glycosylation site {N568}
N-glycosylation site {N591}
N-glycosylation site {N604}
N-glycosylation site {N659}
FG-GAP {718-750}
STATE: active state
Database Correlations
OMIM 602515
UniProt P80108
Pfam PF01839
Kegg hsa:2822
ENZYME 3.1.4.50
References
- Scallon BJ, Fung WJ, Tsang TC, Li S, Kado-Fong H, Huang KS,
Kochan JP.
Primary structure and functional activity of a
phosphatidylinositol-glycan-specific phospholipase D.
Science. 1991 Apr 19;252(5004):446-8.
PMID: 2017684
- UniProt :accession P80108
- Horowitz AM, Fan X, Bieri G et al.
Blood factors transfer beneficial effects of exercise on
neurogenesis and cognition to the aged brain.
Science 2020 Jul 10; 369:167.
PMID: 32646997
https://science.sciencemag.org/content/369/6500/167